Hormonal
Subcutaneous semaglutide (0.5-1.0 mg) and oral semaglutide (7-14 mg) significantly improve glycemic control (HbA1c reduction) in patients with type 2 diabetes compared to placebo and various active control drugs.
For individuals with type 2 diabetes, semaglutide (available as a once-weekly injection or daily oral tablet) is highly effective at lowering blood sugar levels (HbA1c) compared to many other treatments, including insulin and other common diabetes medications. It offers a significant advantage in achieving target HbA1c levels (<7%) for a large proportion of patients. The risk of hypoglycemia is relatively low, and the once-weekly dosing can help improve compliance.
The results after 30–56 weeks show that semaglutide performs significantly better in reducing HbA1c than other controls, including placebo, insulin glargine, canagliflozin, dulaglutide, sitagliptin, liraglutide, and exenatide extended release.
Why this rating
Based on multiple phase-3 clinical trials (SUSTAIN 1-5, 7-10, PIONEER series) involving thousands of patients.
Source
New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation
Yalin Liu et al. · Frontiers of Medicine · 2022
DOI 10.1007/s11684-021-0873-2
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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