Mixed
Polygenic scores derived from 59 SNPs associated with central adiposity predict a smaller reduction in waist circumference after one year of lifestyle intervention, though the effect size is too small to be clinically significant.
Your genes might make it slightly harder to lose belly fat compared to someone else with different genetics, but the difference is less than a centimeter. This is too small to matter for your health goals. Focus on the lifestyle intervention (diet and exercise) as it provides a much larger benefit than any genetic disadvantage.
One-SD higher PS related to a smaller 1-year change in WCadjBMI in the lifestyle intervention arms at year 1 and thus predicted poorer response (b 5 0.007; SE 5 0.003; P 5 0.03) among White participants overall and in White men... These results indicate that polygenic risk estimated from these 59 SNPs relates to change in WCadjBMI with lifestyle intervention, but the effects are small and not of sufficient magnitude to be clinically significant.
Why this rating
Meta-analysis of 7 randomized controlled trials with large sample sizes (n=7,646), though heterogeneity was noted in some subgroups.
Source
Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention: The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention
Jeanne M. McCaffery et al. · Diabetes · 2022
DOI 10.2337/db21-0741
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