Research
Mixed
Human observational studies on MSG and obesity show inconsistent results, with some finding positive associations and others finding no association or inverse associations, largely due to measurement errors and confounding factors.
Human studies on MSG and weight are mixed. While animal studies suggest risks, human data is not conclusive. Reducing intake of processed foods with hidden MSG is a low-risk strategy for overall health.
LimitedQualifiesLOW confidence
overall findings on MSG and adiposity in humans have been limited and mixed. A definitive conclusion is premature based on the existing human data.
Why this rating
Observational studies are prone to bias and measurement error, limiting their strength.
Source
Monosodium glutamate: A hidden risk factor for obesity?
Ka Kahe et al. · Obesity Reviews · 2025
DOI 10.1111/obr.13903
narrative_reviewCited 10×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Chronic consumption of monosodium glutamate (MSG) is associated with increased risk of obesity and weight gain, primarily through mechanisms involving hypothalamic damage, leptin resistance, and altered gut microbiota.Moderate
- MSG consumption may increase food intake and palatability, leading to higher energy intake and potential weight gain, particularly in animal models.Moderate
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
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