Energy balance
Caloric restriction mimetics (CRMs) such as SGLT2 inhibitors, GLP-1 agonists, and specific compounds like spermidine and rapamycin can replicate the beneficial effects of caloric restriction on HFpEF without requiring dietary restriction.
If you have HFpEF and struggle with strict dieting, ask your doctor about medications that mimic the effects of fasting. Drugs like SGLT2 inhibitors and GLP-1 agonists, as well as emerging compounds, may help improve heart function and reduce inflammation without requiring you to eat significantly less.
We discuss the potential for pharmacologically mimicking the beneficial effects of caloric restriction in HFpEF using clinically approved and emerging caloric restriction mimetics... These include protein deacetylation via acetyl-CoA depletion, acetyltransferases inhibition or deacetylases activation, suppression of appetite and nutrient-sensing signalling and stimulating ketogenesis, among others.
Why this rating
The paper reviews preclinical data and some clinical trial results for specific drugs, but many CRMs are still in experimental stages for HFpEF.
Source
Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential
Alexander Fuerlinger et al. · Cardiovascular Diabetology · 2025
DOI 10.1186/s12933-024-02566-8
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →