Mixed
Skeletal muscle hypertrophy following resistance training is associated with distinct, cell-type-specific non-coding RNA (ncRNA) expression patterns, including MYREM (myonuclear), MEG3 (satellite cells), and CARMN (linear association with lean mass gain), which mediate growth via discrete functional pathways rather than uniform bulk tissue changes.
Resistance training works for most people (61% in this large multi-study analysis). If you are not seeing expected gains, it may not be that you 'can't grow,' but that your body uses different molecular switches (ncRNAs) than the average responder. Focus on consistent, supervised resistance training; individual molecular responses vary, but the mechanical stimulus is the primary driver. Do not use 'non-response' as an excuse to stop training, as measurement error often masks small gains.
Our multi-layered analyses established that single-cell-associated ncRNA are identifiable from bulk muscle transcriptomic data and that hypertrophy-linked ncRNA genes mediate their association with muscle growth via multiple cell types and a set of interacting pathways.
Why this rating
Large multi-study cohort (n=144), rigorous filtering, spatial validation (MERSCOPE), but observational/correlational nature of transcriptomics.
Source
Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling
Jonathan C. Mcleod et al. · NAR Molecular Medicine · 2024
DOI 10.1093/narmme/ugae016
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