Research
Mixed
Metabolic surgery is an effective treatment for Non-Alcoholic Steatohepatitis (NASH), significantly reducing liver steatosis, inflammation, and fibrosis, and reducing progression to hepatocellular carcinoma (HCC).
If you have NASH, metabolic surgery is currently the most effective treatment to reverse liver damage and reduce the risk of liver cancer, as current medications and lifestyle changes are largely ineffective.
GoodSupportsHIGH confidence
A recent study by Lassailly et al. showed the beneficial and significant changes in steatosis and NAFLD activity score (NAS) after metabolic surgery... steatosis decreased from 60 to 10% after surgical treatment, and the NAS diminished from 5 to 1, essentially normalizing the liver histology in patients with NASH.
Why this rating
Based on specific studies (Lassailly 2018) and meta-analyses cited.
Source
Comorbidities as an Indication for Metabolic Surgery
Anne-Catherine Schwarz et al. · Visceral Medicine · 2018
DOI 10.1159/000493291
narrative_reviewCited 9×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Metabolic surgery (RYGB, SG, BPD) is more effective than conservative medical therapy for achieving remission of Type 2 Diabetes Mellitus (T2DM) and improving glycemic control, regardless of the patient's preoperative BMI.Good
- Metabolic surgery can reverse or significantly improve existing diabetic microvascular complications, including nephropathy, neuropathy, and retinopathy, independent of the degree of weight loss or glycemic control.Good
- Metabolic surgery reduces overall and cardiovascular mortality in patients with Type 2 Diabetes and obesity, independent of preoperative BMI.Good
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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