Research
Energy balance
Obesity is fundamentally a chronic metabolic disease characterized by disturbances in energy homeostasis and excessive fat accumulation, driven by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors.
Understand that obesity is a complex chronic disease, not a moral failing. Effective management requires addressing biological, genetic, and environmental factors, often necessitating medical interventions alongside lifestyle changes.
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Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors.
Why this rating
This is a comprehensive review article published in Obesity Reviews, citing extensive literature.
Source
The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies
Gašper Tonin et al. · Obesity Reviews · 2025
DOI 10.1111/obr.13978
narrative_reviewCited 7×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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