Hormonal
SGLT2 inhibitors (e.g., empagliflozin, dapagliflozin) and GLP-1 receptor agonists (e.g., liraglutide) provide robust cardiorenal protection in type 2 diabetes, reducing cardiovascular mortality, heart failure hospitalizations, and kidney disease progression independent of glycemic control.
If you have Type 2 Diabetes and heart or kidney issues, standard sugar-lowering drugs may not be enough. Newer classes of drugs (SGLT2 inhibitors like Jardiance/Farxiga and GLP-1 agonists like Ozempic/Victoza) are proven to significantly reduce the risk of heart attacks, heart failure hospitalizations, and kidney failure. These benefits occur even if your blood sugar numbers don't change drastically, so discuss these specific organ-protective benefits with your doctor.
novel agents such as the sodium-glucose cotransporter type 2 (SGLT2) inhibitors and glucagon-like peptide receptor agonists (GLP-1 RAs) demonstrating robust evidence in cardiorenal protection... The significant cardiovascular risk reduction observed in these landmark trials established a new paradigm in T2DM management, shifting the traditional glucose-centric approach to one that emphasizes cardiovascular risk reduction.
Why this rating
Based on multiple large-scale Cardiovascular Outcome Trials (CVOTs) like EMPA-REG, LEADER, DAPA-HF, and CREDENCE.
Source
Novel Therapeutics for Type 2 Diabetes Mellitus—A Look at the Past Decade and a Glimpse into the Future
Ying Jie Chee et al. · Biomedicines · 2024
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