Research
Hormonal
SGLT2 inhibitors improve vascular function by reducing arterial stiffness, improving endothelial function (flow-mediated dilation), and reducing inflammation and oxidative stress.
These drugs don't just lower sugar; they physically improve the health of your blood vessels by making them more flexible and reducing the chemical stress (inflammation/oxidative stress) that damages them over time.
GoodSupportsHIGH confidence
SGLT2 inhibition has been shown to improve arterial stiffness... SGLT2 inhibitors reduce vascular inflammation... SGLT2 inhibition has been shown to reduce leukocyte mitochondrial superoxide production... The DEFENCE trial showed that 16 weeks of dapagliflozin reduced urine 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative stress.
Why this rating
Supported by multiple meta-analyses and RCTs (DEFENCE, etc.), though some markers (CRP) show mixed results.
Source
Novel Therapeutics for Type 2 Diabetes Mellitus—A Look at the Past Decade and a Glimpse into the Future
Ying Jie Chee et al. · Biomedicines · 2024
DOI 10.3390/biomedicines12071386
narrative_reviewCited 6×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
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