Mixed

N-of-1 study designs provide a higher level of evidence for determining individualized treatment efficacy in medical nutrition therapy compared to traditional Randomized Controlled Trials (RCTs), which often mask individual variance through mean effect sizes.

If you are a dietitian, standard RCT-based guidelines may not work for every patient because individual responses vary widely. To practice true precision nutrition, consider using N-of-1 trial designs (testing one patient against themselves with multiple diet phases) to identify the specific dietary pattern that works for that individual's biology and lifestyle, rather than relying solely on population averages.