Research

Hormonal

Metformin therapy reduces the incidence of new-onset type 2 diabetes in high-risk adults (BMI ≥35, age 25-59, fasting glucose ≥110 mg/dL, or prior gestational diabetes) and provides long-term cardiovascular and microvascular benefits.

If you are at high risk for type 2 diabetes (overweight, older than 25, or have a history of gestational diabetes), metformin can help prevent the disease. It is cost-effective and provides long-term benefits even after stopping the drug. Discuss with your doctor if you are a candidate, especially if lifestyle changes alone are insufficient.

StrongSupportsHIGH confidence
Metformin is recommended to prevent type 2 diabetes in adults aged 25–59 years, with BMI ≥ 35 kg/m2, fasting glucose ≥ 110 mg/dL, glycated hemoglobin ≥ 6.0%, and in women with prior gestational diabetes
Nicholas W. Carris et al. · Diabetes Therapy · 2023

Why this rating

Based on DPP/DPPOS data showing sustained benefit and cost-effectiveness.

Source

A Systematic Approach to Treating Early Metabolic Disease and Prediabetes

Nicholas W. Carris et al. · Diabetes Therapy · 2023

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