Research
Hormonal
Non-sulfated CCK peptides stimulate gastric acid secretion via CCK2 receptors, acting similarly to gastrin, whereas sulfated CCK inhibits acid secretion via CCK1 receptors.
The form of CCK matters. In rare tumors (CCKoma), non-sulfated CCK can cause ulcers by stimulating acid. In healthy individuals, sulfated CCK inhibits acid. This distinction is crucial for understanding gastric pathologies.
GoodSupportsHIGH confidence
In contrast, non-sulfated CCK peptides stimulate gastric acid secretion via CCK2-receptors on gastric ECL cells. In other words, non-sulfated CCK acts like gastrin.
Why this rating
Based on established receptor pharmacology and clinical observations of CCKoma syndrome.
Source
Cholecystokinin: Clinical aspects of the new biology
Jens F. Rehfeld · Journal of Internal Medicine · 2025
DOI 10.1111/joim.20110
narrative_reviewCited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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