Mixed
Higher BMI categories, particularly Class III obesity (BMI ≥40 kg/m2), are strongly associated with worse self-reported overall health, quality of life, severe pain, fatigue, and limited physical activity, as well as an increased risk of developing chronic pain syndrome, chronic fatigue syndrome, fibromyalgia, and insomnia.
If you have obesity, do not ignore persistent pain, fatigue, or sleep issues. These are not just 'side effects' of weight but significant health risks linked to conditions like fibromyalgia and chronic fatigue. Seek medical evaluation for these symptoms, as treating them can improve your quality of life and functional ability, independent of weight loss goals.
Higher BMI categories were increasingly associated with poorer self-reported overall health, QoL, and health metrics, compared with the normal weight group... Individuals with obesity had an elevated risk of developing CFS, CPS, fibromyalgia, and insomnia, compared with those with normal weight, with the strongest associations observed in Class III obesity.
Why this rating
Large longitudinal cohort (n=323,640) with robust statistical adjustments and clear dose-response relationships.
Source
Adverse effects of obesity on overall health, quality of life, and related physical health metrics: A cross‐sectional and longitudinal study from the All of Us Research Program
Zhiqi Yao et al. · Journal of Internal Medicine · 2025
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