Research
Macro partitioning
A daily protein intake of approximately 1.6 grams per kilogram of body weight is recommended to spare lean body mass during weight loss induced by GLP-1 medications.
When losing weight on GLP-1s, aim to eat approximately 1.6 grams of protein for every kilogram of your body weight each day. This specific target helps protect your muscle mass from being lost along with the fat.
GoodSupportsHIGH confidence
Currently, most evidence suggests that ~1.6 grams of protein per kilogram is the recommended daily target for protein intake to spare lean body mass loss during periods of weight loss.
Why this rating
Cited as 'most evidence suggests', referencing specific literature (ref 28).
Source
Knowing Well, Being Well: well-being born of understanding: Access to GLP-1s: Where Do Employers Fit in?
Mary T. Imboden · American Journal of Health Promotion · 2025
DOI 10.1177/08901171251335507
narrative_reviewCited 3×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Combining GLP-1 receptor agonists with resistance and aerobic exercise training yields greater fat loss and better preservation of lean muscle mass compared to GLP-1 use alone.Good
- Discontinuation of GLP-1 medications leads to rapid weight regain (up to two-thirds of prior loss) and worsening cardiometabolic health, disproportionately affecting underserved communities.Good
Related findings · Macro partitioning
- Total daily protein intake of 1.6 g/kg/day is sufficient for maximizing resistance training-induced muscle gains, with an upper confidence interval of 2.2 g/kg/day.Strong
- Resistance exercise training combined with sufficient dietary protein intake acts synergistically to maximize skeletal muscle hypertrophy, with protein intake saturating around 1.6 g/kg/day for general populations and potentially requiring 2.0-2.2 g/kg/day for resistance-trained individuals.Strong
- Trans fats should be completely eliminated from the diet, as they increase LDL cholesterol, decrease HDL cholesterol, and are directly associated with increased coronary risk.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →