Mixed
Combining GLP-1 receptor agonists with resistance and aerobic exercise training yields greater fat loss and better preservation of lean muscle mass compared to GLP-1 use alone.
If you are prescribed a GLP-1 medication for weight loss, do not rely on the drug alone. You must combine it with resistance and aerobic exercise. This combination is critical to ensure you lose fat rather than muscle, preserving your metabolic health and physical function.
research shows that when resistance and aerobic exercise is combined with GLP-1 use, greater weight loss is achieved than with GLP-1s alone. Additionally, of the weight lost, those combining exercise and GLP-1 use have a greater percent reduction of body fat loss than GLP-1s alone, indicating a better maintenance of lean mass.
Why this rating
The paper cites a specific randomized placebo-controlled trial (Jensen et al., ref 27) supporting the claim, though it is a commentary/editorial piece summarizing other works.
Source
Knowing Well, Being Well: well-being born of understanding: Access to GLP-1s: Where Do Employers Fit in?
Mary T. Imboden · American Journal of Health Promotion · 2025
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →