Research
Mixed
Concomitant use of SGLT2 inhibitors significantly enhances weight loss in patients taking GLP-1 receptor agonists, independent of the specific GLP-1 RA used.
If weight loss stalls on a GLP-1 RA, discuss adding an SGLT2 inhibitor. This study found that using both together significantly improved weight loss outcomes compared to using GLP-1 RAs alone, likely due to complementary mechanisms.
ModerateSupportsMEDIUM confidence
baseline weight, diabetes, and SGLT2 inhibitors were significant factors affecting weight... The results did not show a significant difference between the two study drugs after adjusting for confounders... However, baseline weight, diabetes status, and the use of SGLT2 inhibitors (SGLT2is) were identified as significant factors influencing weight loss.
Why this rating
Retrospective observational data; association is strong but causality is harder to establish than in RCTs.
Source
Comparing the Efficacy of Liraglutide and Semaglutide on Weight Loss: Experience from the Middle East Gulf Region and Literature Review
Wasim S. El Nekidy et al. · Hospital Pharmacy · 2025
DOI 10.1177/00185787251340645
cohort · n=366Cited 3×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Mixed
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