Hormonal
Higher baseline BMI and the presence of symptomatic comorbidities (specifically knee osteoarthritis or obstructive sleep apnoea) are associated with greater improvements in health utility scores following semaglutide 2.4 mg treatment.
If you have a higher BMI (over 35 or 40) and suffer from knee osteoarthritis or sleep apnea, semaglutide 2.4 mg once weekly may offer even greater improvements in your daily health quality of life than it would for someone with a lower BMI or fewer comorbidities.
A greater treatment effect was noted in subgroups with presence of symptomatic comorbidities, i.e. 0.077 (0.027-0.128) to 0.105 (0.030-0.179) at week 68.
Why this rating
Post-hoc subgroup analyses are exploratory and not adjusted for multiple comparisons, reducing certainty compared to the primary endpoint.
Source
Treatment effect of semaglutide 2.4 mg on health‐related quality of life from <scp>STEP</scp> 1 <scp>SF‐6D</scp> derived from <scp>SF</scp> ‐36 with Australian weights
Pavol Kral et al. · Diabetes Obesity and Metabolism · 2024
DOI 10.1111/dom.15426
More from this paper
- Semaglutide 2.4 mg administered once weekly for 68 weeks significantly improves health-related quality of life (HRQoL) utility scores compared to placebo in adults with overweight or obesity.Good
- Each unit increase in baseline BMI is associated with a statistically significant decrease in health utility scores, indicating that higher obesity severity correlates with lower quality of life.Good
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