Macro partitioning

A longitudinal dietary pattern characterized by decreasing low-carbohydrate intake and increasing high-fat intake is associated with a lower risk of all-cause mortality in males, despite being associated with a higher risk of obesity.

For men in this demographic, shifting dietary habits to reduce carbohydrate intake (specifically from a low baseline) while allowing fat intake to increase over time is associated with a lower risk of death, though it comes with a higher risk of obesity. This suggests that for long-term survival, macronutrient quality and trajectory may matter more than total fat avoidance, but weight management remains a challenge.