Research
Energy balance
BMI mediates the association between macronutrient quality and phenotypic age acceleration, accounting for approximately 20-30% of the effect.
Dietary changes slow aging partly by helping you maintain a healthy weight. If you are trying to slow biological aging, combining high-quality food choices with weight management strategies will be more effective than diet alone.
ModerateQualifiesMEDIUM confidence
The ratio between BMI-mediated high-quality carbohydrates and PhenoAgeAccel accounted for 19.76% of the total effect, while the ratio between BMI-mediated total fat and PhenoAgeAccel accounted for 30.78% of the total effect.
Why this rating
Mediation analysis in an observational study; establishes association, not causation of the mediation path.
Source
BMI Mediates the Association between Macronutrient Subtypes and Phenotypic Age Acceleration
Kai He et al. · Nutrients · 2024
DOI 10.3390/nu16203436
cross_sectional · n=6911Cited 3×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Replacing servings of low-quality carbohydrates or animal protein with high-quality carbohydrates or plant protein reduces phenotypic age acceleration (PhenoAgeAccel).Moderate
- High-quality carbohydrate intake is associated with reduced phenotypic age acceleration, but the relationship is non-linear, with potential adverse effects at excessive intake levels.Moderate
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