Energy balance

A 3-month intervention combining alternate day fasting (600 kcal on fast days) and moderate-intensity aerobic exercise significantly reduces intrahepatic triglyceride content and associated cardiometabolic risk in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).

For patients with fatty liver disease, a 3-month program of Alternate Day Fasting (eating 600 calories on fast days, normal on others) combined with 5 weekly sessions of moderate exercise (like brisk walking or cycling) significantly reduces liver fat. This approach is a validated, mainstay therapy that works by creating a caloric deficit and improving metabolic markers, even without drastic daily calorie counting.