Mixed
GLP-1 receptor agonists, particularly semaglutide and tirzepatide, are associated with an increased risk of non-scarring hair loss (telogen effluvium and androgenetic alopecia), primarily driven by rapid weight loss and nutritional deficits rather than direct drug toxicity.
If you are using semaglutide or tirzepatide and notice hair shedding, it is likely due to rapid weight loss or nutritional deficits rather than permanent drug damage. Ensure adequate protein and micronutrient intake (iron, zinc) and consider slowing dose escalation. The risk is highest with these specific drugs and in females, but often stabilizes as weight loss plateaus.
Accumulating evidence from pharmacovigilance databases and clinical cohorts suggests an increased risk of hair loss with certain GLP-1 RAs, particularly semaglutide and tirzepatide... Rapid weight loss emerged as a potential contributor, particularly for telogen effluvium.
Why this rating
Evidence is largely from pharmacovigilance and retrospective cohorts; randomized trials show modest but consistent signals, but causality is not fully established.
Source
GLP-1 therapies and hair loss: A systematic review of current evidence and implications for counseling
Aditya K. Gupta et al. · Science Progress · 2026
DOI 10.1177/00368504261444578
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