Mixed
Vitamin D3 supplementation alone is the most cost-effective management strategy for sarcopenia in Iran, whereas combination therapies (Protein+Vitamin D, Protein+Vitamin D+Exercise) are not cost-effective despite higher clinical effectiveness.
For healthcare systems or individuals in Iran, Vitamin D3 supplementation is the most economically sensible intervention for managing sarcopenia. While adding protein and exercise improves health outcomes (QALYs), the high cost of these combinations makes them not cost-effective compared to Vitamin D alone. Focus on Vitamin D for the best economic return.
base-case results indicated that vitamin D was the cost-effective strategy. Other combination strategies with vitamin D... despite the higher effectiveness and the increase in the amount of QALYs obtained, according to Iran's cost-effectiveness threshold were not cost-effective.
Why this rating
It is a secondary economic modeling study (Markov model) relying on literature-derived parameters rather than primary clinical trial data for all interventions.
Source
Economic Evaluation of Sarcopenia Management Interventions; a Lifetime Cost-Utility Analysis in Iran
Ali Darvishi et al. · Research Square · 2023
DOI 10.21203/rs.3.rs-2492355/v1
Related findings · Mixed
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