Research
Energy balance
The physiological mechanism of diabetes remission via weight loss involves the reduction of ectopic fat in the liver and pancreas, which restores beta-cell function and insulin sensitivity.
N/A (Mechanistic explanation).
StrongSupportsHIGH confidence
Pathophysiological studies have demonstrated that the reduction of visceral fat resulting from weight loss may be the primary mechanism contributing to diabetes remission. Excessive fat deposition in organs and tissues, such as the liver and pancreas, can increase insulin resistance and hinder the β-cell redifferentiation in the body.
Why this rating
Supported by multiple pathophysiological studies and animal models cited in the review.
Source
Recent progress of remission in type 2 diabetes
Zhiyi Zhao et al. · Therapeutic Advances in Endocrinology and Metabolism · 2025
DOI 10.1177/20420188251408210
narrative_reviewCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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