Hormonal
Short-term overnutrition directly impairs thyroid hormone biosynthesis and peripheral T4-to-T3 conversion, causing hypothyroidism and reduced energy expenditure, despite compensatory thyroidal adaptations.
Obesity can directly damage thyroid function and slow metabolism, creating a vicious cycle. However, this damage is largely reversible with weight loss. Focus on sustainable caloric reduction rather than seeking thyroid fixes alone, as the thyroid dysfunction is a symptom of overnutrition, not the root cause.
Overnutrition directly impairs thyroid hormone biosynthesis and utilization, causing hypothyroidism, despite remarkable thyroidal adaptations
Why this rating
Strong mechanistic evidence in mice with translational histological correlation in humans, but preclinical.
Source
Overnutrition directly impairs thyroid hormone biosynthesis and utilization, causing hypothyroidism, despite remarkable thyroidal adaptations
Jessica Rampy et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2025
DOI 10.1101/2025.03.31.645596
More from this paper
- Overnutrition reduces whole-body energy expenditure by impairing peripheral T4-to-T3 conversion via decreased D2 activity, rendering obese individuals resistant to T4 therapy.Good
- Thyroid dysfunction and structural changes caused by overnutrition are largely reversible through weight loss and return to a normal diet.Good
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