Research
Hormonal
Overnutrition reduces whole-body energy expenditure by impairing peripheral T4-to-T3 conversion via decreased D2 activity, rendering obese individuals resistant to T4 therapy.
Obesity impairs your body's ability to convert T4 into active T3, which lowers your metabolism and makes T4 supplements less effective for weight loss. The solution is not more thyroid medication, but weight loss, which restores normal thyroid function.
GoodSupportsHIGH confidence
Overnutrition additionally suppressed T4 activation, rendering the mice resistant to T4 and reducing EE.
Why this rating
Strong mechanistic data in mice, with human translational hints.
Source
Overnutrition directly impairs thyroid hormone biosynthesis and utilization, causing hypothyroidism, despite remarkable thyroidal adaptations
Jessica Rampy et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2025
DOI 10.1101/2025.03.31.645596
preprint
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Short-term overnutrition directly impairs thyroid hormone biosynthesis and peripheral T4-to-T3 conversion, causing hypothyroidism and reduced energy expenditure, despite compensatory thyroidal adaptations.Good
- Thyroid dysfunction and structural changes caused by overnutrition are largely reversible through weight loss and return to a normal diet.Good
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