Mixed
The presence of cardiovascular (CV) or metabolic comorbidities significantly reduces health-related quality of life (HRQoL) and work productivity in people with overweight or obesity, often more so than BMI alone.
Having overweight or obesity is only part of the story. If you also have heart or metabolic conditions (like diabetes), your quality of life and work productivity are likely significantly lower than someone with the same BMI but no comorbidities. Treating these specific conditions is crucial for your well-being.
Scores for physical functioning... were lower (P < .05) in PLwO with cardiovascular comorbidities than in those without. PLwO with metabolic comorbidities had lower scores than those without for... mental health... (P < .05).
Why this rating
Cross-sectional survey with small sample size for survey respondents (n=119), limiting generalizability.
Source
Impact of Body Mass Index and Comorbidities on Health-Related Quality of Life and Work Productivity in People With Overweight or Obesity: A Survey-Based Study in the United Kingdom
Andrea Leith et al. · Journal of health economics and outcomes research · 2025
DOI 10.36469/001c.141081
More from this paper
- Higher body mass index (BMI) is associated with lower self-reported physical functioning and overall health-related quality of life (HRQoL) in people with overweight or obesity.Moderate
- People with overweight or obesity and metabolic comorbidities experience significantly higher work impairment (activity impairment and presenteeism) compared to those without such comorbidities.Moderate
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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