Research
Hormonal
Adipose tissue dysfunction, characterized by chronic low-grade inflammation and insulin resistance, creates a self-perpetuating cycle that promotes obesity.
Excess fat, especially around the abdomen, is not just inert storage but an active organ that releases inflammatory signals. These signals can cause insulin resistance and further fat storage, creating a cycle that is hard to break without addressing the underlying inflammation.
ModerateSupportsMEDIUM confidence
The hypertrophy of adipose cells in obesity often exceeds the capacity for adipocyte hyperplasia. This leads to mechanical stress, cellular hypoxia, and recruitment of pro-inflammatory macrophages, resulting in chronic low-grade inflammation and systemic insulin resistance.
Why this rating
Review of multiple studies on adipose tissue biology.
Source
Molecular Mechanisms Against Successful Weight Loss and Promising Treatment Options in Obesity
Zsolt Szekeres et al. · Biomedicines · 2025
DOI 10.3390/biomedicines13081989
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Obesity involves molecular mechanisms, including metabolic memory and epigenetic modifications, that actively hinder weight loss and promote weight regain.Moderate
- Epigenetic changes, such as DNA methylation and histone modifications, can persist after weight loss and contribute to weight regain.Moderate
- Current interventions, including calorie restriction, physical activity, and pharmacological treatment, show promise in combating obesity, but long-term efficacy and safety need further establishment.Moderate
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