Research
Mixed
Current interventions, including calorie restriction, physical activity, and pharmacological treatment, show promise in combating obesity, but long-term efficacy and safety need further establishment.
There is no single magic bullet for obesity. The most promising approach combines lifestyle changes (diet and exercise) with medical treatments if necessary. However, long-term success is not guaranteed, and ongoing management is likely required.
ModerateQualifiesMEDIUM confidence
Current interventions, including calorie restriction, physical activity, and pharmacological treatment together, may show great promise in combating obesity, but long-term efficacy and safety remain to be established.
Why this rating
Review of multiple studies.
Source
Molecular Mechanisms Against Successful Weight Loss and Promising Treatment Options in Obesity
Zsolt Szekeres et al. · Biomedicines · 2025
DOI 10.3390/biomedicines13081989
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Obesity involves molecular mechanisms, including metabolic memory and epigenetic modifications, that actively hinder weight loss and promote weight regain.Moderate
- Epigenetic changes, such as DNA methylation and histone modifications, can persist after weight loss and contribute to weight regain.Moderate
- Adipose tissue dysfunction, characterized by chronic low-grade inflammation and insulin resistance, creates a self-perpetuating cycle that promotes obesity.Moderate
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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