Research
Mixed
Genotype-based dietary interventions (low-carb vs. low-fat) do not significantly impact weight loss outcomes, suggesting that genotyping alone is not an effective precision medicine approach for weight loss.
Don't pay for expensive genetic testing to tell you whether to eat low-carb or low-fat. Current high-quality evidence shows that your genotype does not predict whether you will lose more weight on one diet versus the other. Focus on finding a dietary pattern you can adhere to consistently that creates a caloric deficit.
GoodRefutesHIGH confidence
Results from both the DIETFITS and POINTS trials showed that genotypes did not impact weight loss with the respective dietary intervention [92, 94], suggesting that genotyping alone may not be an effective precision medicine approach for weight loss or that the genotypes associated with weight loss response have not yet been properly identified or matched to appropriate intervention approaches.
Why this rating
Based on two large, well-designed RCTs (DIETFITS and POINTS) cited in the review.
Source
Precision Prevention, Diagnostics, and Treatment of Obesity: Pipedream or Reality?
Emily K. Woolf et al. · Obesity · 2025
DOI 10.1002/oby.70015
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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