Research
Micronutrients & recovery
Incretin-based therapies may attenuate intestinal iron absorption, independent of reduced intake, potentially contributing to iron deficiency in susceptible individuals.
Monitor iron levels if you have a history of anemia or low iron, as semaglutide may slightly reduce absorption.
LimitedSupportsLOW confidence
A pilot study assessing intestinal iron absorption using an oral iron absorption test before and after initiation of semaglutide demonstrated attenuated intestinal iron absorption, with a median reduction of 13% after 10 weeks of treatment [33].
Why this rating
Based on a small pilot study (N=?? implied small) with short duration.
Source
Micronutrient Deficiencies in the Era of Second-Generation Incretin-Based Therapies for Obesity
Andrijana Koceva et al. · Nutrients · 2026
DOI 10.3390/nu18040677
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Second-generation incretin-based therapies (semaglutide, tirzepatide) increase the risk of micronutrient deficiencies and related complications, primarily through reduced dietary intake and altered food selection, with real-world data showing a 22.4% incidence of recorded nutritional deficiencies at 12 months.Moderate
- Incretin-based therapies alter dietary patterns by reducing cravings for high-fat and sugary foods, which may displace micronutrient-dense food groups if not actively managed.Moderate
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