Energy balance
Oriental Melon Stem Ethanol Extract (CMSE) reduces body weight and fat mass in high-fat diet-induced obese mice by increasing energy expenditure and enhancing brown adipose tissue thermogenesis, independent of calorie intake.
If you are looking for a supplement to support weight management, Oriental Melon Stem Extract (CMSE) shows promise in animal studies for boosting metabolism and burning fat without needing to eat less. The effective dose in mice translates to a high daily intake for humans (~2.3g), which falls within the range of dietary supplements. While not a magic bullet, it may support metabolic health and liver function when combined with a balanced diet.
CMSE treatment significantly reduced body weight and fat mass in HFD-induced obese mice by enhancing energy expenditure, independent of calorie intake. It also ameliorated hepatic steatosis... CMSE contributed to the stimulation of thermogenesis and energy dissipation in brown adipose tissue (BAT) by increasing the expression of thermogenic genes (Ucp-1 and Ucp-3) and elevating uncoupling protein 1 (UCP-1) protein levels.
Why this rating
Evidence is from animal models (mice) using a high-fat diet; human clinical data is not provided.
Source
Upcycling Agricultural By‐Product: Therapeutic Potential of Oriental Melon Stem ( <i>Cucumis melo var. makuwa</i> ) in Treating Obesity and Fatty Liver via Enhanced Thermogenesis
Myeong‐Jin Kim et al. · Food Frontiers · 2026
DOI 10.1002/fft2.70246
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