Research
Mixed
Osteosarcopenia is defined by the simultaneous loss of muscle mass, muscle strength, bone mass, and functional capacity, and is associated with significantly higher risks of falls, fractures, and mortality compared to having either condition alone.
Osteosarcopenia is the dangerous combination of weak muscles and weak bones. It significantly increases your risk of falls, fractures, and death compared to having just one of these conditions. A comprehensive assessment should check both muscle and bone health.
StrongSupportsHIGH confidence
Once a threshold has been reached whereby there is a simultaneous loss of muscle and bone mass, as well as muscle strength and functional capacity, osteosarcopenia occurs [1]. A one‐year follow‐up study of older adults with hip fracture showed that those with osteosarcopenia had a significantly greater mortality risk at one year (15.1%), than those with sarcopenia (10.3%) or osteoporosis alone (5.1%) [70].
Why this rating
Supported by systematic reviews, meta-analyses, and longitudinal studies showing clear associations with adverse outcomes.
Source
Osteosarcopenia
Ben Kirk et al. · 2021
DOI 10.1002/9781119597896.ch11
book_chapter
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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