Research
Energy balance
Transitioning from non-obese to obese status or maintaining obesity significantly increases the risk of MASLD, with risk escalating with age and magnitude of weight gain.
Gaining weight, especially transitioning from a normal weight to obese, drastically increases your risk of fatty liver disease. The more weight you gain (especially >20kg), the higher the risk. Maintaining a stable, non-obese weight is the most protective strategy.
ModerateSupportsMEDIUM confidence
The risk of MASLD increases in individuals transitioning from non-obese to obese or maintaining obesity... a weight gain of > 20 kg increased the risk of MASLD by 4.78 times that of the reference group
Why this rating
Retrospective observational study.
Source
Association between weight fluctuation and the risk of metabolic dysfunction-associated steatotic liver disease
Jinping Wang et al. · World Journal of Hepatology · 2025
DOI 10.4254/wjh.v17.i5.103852
cohort · n=8191
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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