Research
Hormonal
Discontinuation of second-generation OMMs leads to significant weight regain, highlighting the chronic nature of obesity and the need for long-term management or intensive lifestyle support upon discontinuation.
Stopping OMMs typically leads to significant weight regain. If you choose to discontinue, work with your healthcare provider to intensify lifestyle interventions, including dietary strategies and physical activity, to help maintain your weight loss.
StrongSupportsHIGH confidence
In the STEP 4 trial, after the semaglutide lead-in those who continued on semaglutide lost an additional − 7.9% while those on placebo gained + 6.9% [77].
Why this rating
Based on multiple randomized withdrawal trials (STEP 4, SURMOUNT-4).
Source
To Reenvision and Redefine: Considering the Role of Lifestyle Interventions in the New Era of Second-Generation Obesity Management Medications
Alexandra Peary et al. · Current Atherosclerosis Reports · 2026
narrative_review
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →