Mixed
Lifestyle interventions during OMM treatment should shift focus from caloric deficit for weight loss to optimizing health, specifically by mitigating lean mass loss through high protein intake and resistance training.
While taking OMMs, prioritize consuming 1.5g of protein per kg of fat-free mass (or 80-120g daily) and engage in resistance training 2-3 times per week. This helps preserve muscle mass and strength, which can be lost during rapid weight loss, and supports overall physical function.
During treatment, lifestyle approaches can mitigate medication-related effects and enhance health beyond weight loss, addressing concerns such as inadequate nutrition or muscle loss through protein intake and physical activity and reducing gastrointestinal side effects via dietary strategies.
Why this rating
Based on guidelines and expert consensus, though specific RCT data on optimal protocols is noted as lacking.
Source
To Reenvision and Redefine: Considering the Role of Lifestyle Interventions in the New Era of Second-Generation Obesity Management Medications
Alexandra Peary et al. · Current Atherosclerosis Reports · 2026
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