Research
Adherence
Bupropion and varenicline are effective interventions for reducing tobacco smoking in persons with serious mental illness, with high-strength evidence.
If you have a serious mental illness and smoke, using bupropion or varenicline is a highly effective, evidence-based strategy to quit. This directly addresses a major health-risk behavior that contributes to premature mortality in this population.
StrongSupportsHIGH confidence
The strength of the evidence was high for 2 interventions: the best available evidence suggested that bupropion had beneficial effects on point and continuous abstinence from tobacco smoking... and that varenicline had beneficial effects on both point and continuous abstinence.
Why this rating
Rated 'high' strength of evidence by the authors.
Source
Interventions to Address Medical Conditions and Health-Risk Behaviors Among Persons With Serious Mental Illness: A Comprehensive Review
Emma E. McGinty et al. · Schizophrenia Bulletin · 2015
DOI 10.1093/schbul/sbv101
systematic_reviewCited 135×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →