Mixed
Metformin and behavioral interventions produce beneficial weight loss in persons with serious mental illness (SMI), with high-strength evidence for both.
If you have a serious mental illness and are struggling with weight, combining metformin with behavioral lifestyle changes is a highly effective, evidence-based strategy. This approach directly addresses the metabolic risks that contribute to premature mortality in this population.
The strength of the evidence was high for 4 interventions: metformin and behavioral interventions had beneficial effects on weight loss
Why this rating
Rated 'high' strength of evidence by the authors based on multiple RCTs and observational studies.
Source
Interventions to Address Medical Conditions and Health-Risk Behaviors Among Persons With Serious Mental Illness: A Comprehensive Review
Emma E. McGinty et al. · Schizophrenia Bulletin · 2015
DOI 10.1093/schbul/sbv101
More from this paper
- Bupropion and varenicline are effective interventions for reducing tobacco smoking in persons with serious mental illness, with high-strength evidence.Strong
- Most other interventions for medical conditions and health-risk behaviors in SMI populations have low or insufficient strength of evidence.Strong
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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