Research
Mixed
Metformin and behavioral interventions produce beneficial weight loss in persons with serious mental illness (SMI), with high-strength evidence for both.
If you have a serious mental illness and are struggling with weight, combining metformin with behavioral lifestyle changes is a highly effective, evidence-based strategy. This approach directly addresses the metabolic risks that contribute to premature mortality in this population.
StrongSupportsHIGH confidence
The strength of the evidence was high for 4 interventions: metformin and behavioral interventions had beneficial effects on weight loss
Why this rating
Rated 'high' strength of evidence by the authors based on multiple RCTs and observational studies.
Source
Interventions to Address Medical Conditions and Health-Risk Behaviors Among Persons With Serious Mental Illness: A Comprehensive Review
Emma E. McGinty et al. · Schizophrenia Bulletin · 2015
systematic_reviewCited 135×
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