Mixed
A cumulative deficit frailty index, constructed from 26 non-traditional health deficits, is a stronger predictor of cardiovascular events and mortality than traditional risk scores (like Framingham) and provides incremental prognostic value independent of those traditional factors.
If you are over 65 or have heart disease risk factors, ask your doctor to assess your 'frailty' using a deficit accumulation model (checking for symptoms, lab abnormalities, and functional limitations), not just standard cholesterol and blood pressure numbers. This assessment predicts heart attacks and death more accurately than traditional scores and can help prioritize preventive care.
The cumulative deficit index statistically outperformed the Framingham score in its ability to discriminate CVD events (C-statistic, 0.60 [95% CI, 0.60–0.61] versus 0.58 [95% CI, 0.57–0.58], respectively; P<0.001)... The frail group (n=13 872) had higher risk of a CVD event (incidence rate ratio, 1.97; 95% CI, 1.85–2.08), all-cause mortality (hazard ratio, 1.91; 95% CI, 1.79–2.03), and CVD mortality (hazard ratio, 1.91; 95% CI, 1.77–2.05) than the nonfrail group (n=101 343).
Why this rating
Large-scale pooled analysis of 154,696 individuals from 14 randomized controlled trials with adjudicated outcomes.
Source
Accumulation of Deficits as a Key Risk Factor for Cardiovascular Morbidity and Mortality: A Pooled Analysis of 154 000 Individuals
Mohammed A. Farooqi et al. · Journal of the American Heart Association · 2020
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →