Mixed
In low-income countries (LIC), the excess cardiovascular and all-cause mortality associated with diabetes remains high and is not significantly attenuated by standard pharmacological treatments (antidiabetes, antihypertensive, lipid-lowering drugs, and aspirin), unlike in high-income countries where treatment substantially reduces this risk.
For patients in low-income settings, having a diabetes diagnosis carries a significantly higher mortality risk than in wealthy nations, and simply taking prescribed medications (for blood sugar, blood pressure, or cholesterol) does not fully mitigate this risk. This is due to systemic issues like low medication adherence, suboptimal dosing, lack of access to acute cardiac care (like angioplasty), and socioeconomic disparities. To reduce mortality, access to care must be improved beyond just medication availability, including affordable acute interventions and better disease management.
In contrast to HIC and MIC, the increased CV mortality in those with diabetes in LIC remained unchanged even after adjustment for behavioral risk factors and treatments (hazard ratio [95% CI] 1.89 [1.58–2.27] to 1.78 [1.36–2.34]).
Why this rating
Large cohort study (n=143,567) across 21 countries with standardized methods and long follow-up (mean 9 years), though observational design limits causal inference for treatment efficacy.
Source
Contrasting Associations Between Diabetes and Cardiovascular Mortality Rates in Low-, Middle-, and High-Income Countries: Cohort Study Data From 143,567 Individuals in 21 Countries in the PURE Study
Ranjit Mohan Anjana et al. · Diabetes Care · 2020
DOI 10.2337/dc20-0886
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