Research

Mixed

In low-income countries (LIC), the excess cardiovascular and all-cause mortality associated with diabetes remains high and is not significantly attenuated by standard pharmacological treatments (antidiabetes, antihypertensive, lipid-lowering drugs, and aspirin), unlike in high-income countries where treatment substantially reduces this risk.

For patients in low-income settings, having a diabetes diagnosis carries a significantly higher mortality risk than in wealthy nations, and simply taking prescribed medications (for blood sugar, blood pressure, or cholesterol) does not fully mitigate this risk. This is due to systemic issues like low medication adherence, suboptimal dosing, lack of access to acute cardiac care (like angioplasty), and socioeconomic disparities. To reduce mortality, access to care must be improved beyond just medication availability, including affordable acute interventions and better disease management.

GoodQualifiesHIGH confidence
In contrast to HIC and MIC, the increased CV mortality in those with diabetes in LIC remained unchanged even after adjustment for behavioral risk factors and treatments (hazard ratio [95% CI] 1.89 [1.58–2.27] to 1.78 [1.36–2.34]).
Ranjit Mohan Anjana et al. · Diabetes Care · 2020

Why this rating

Large cohort study (n=143,567) across 21 countries with standardized methods and long follow-up (mean 9 years), though observational design limits causal inference for treatment efficacy.

Source

Contrasting Associations Between Diabetes and Cardiovascular Mortality Rates in Low-, Middle-, and High-Income Countries: Cohort Study Data From 143,567 Individuals in 21 Countries in the PURE Study

Ranjit Mohan Anjana et al. · Diabetes Care · 2020

DOI 10.2337/dc20-0886

cohort · n=143567Cited 64×
Read the paper
DOI resolved against Crossref · corpus check 2026-06-10

This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →