Research
Mixed
Familiarity with the exercise modality significantly reduces the magnitude of biomarker elevation and the severity of Delayed Onset Muscle Soreness (DOMS) due to physiological adaptations.
When starting a new running routine or increasing intensity, expect significant muscle soreness and elevated biomarkers. This is normal. As you repeat the activity, your body adapts, reducing soreness and biomarker spikes, which is a sign of improved resilience.
GoodSupportsHIGH confidence
An interesting characteristic of DOMS is that after the initial bout of exercise, adaptations occur to provide some protection against the future occurrence of DOMS and reduce its severity.
Why this rating
Supported by multiple studies cited in the review regarding DOMS and biomarker recovery.
Source
Acute changes to biomarkers as a consequence of prolonged strenuous running
Stephen R. Bird et al. · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · 2013
DOI 10.1177/0004563213492147
narrative_reviewCited 58×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Prolonged strenuous running (e.g., marathons, ultra-marathons) causes acute, transient elevations in biomarkers typically associated with pathology (such as creatine kinase, cardiac troponins, and liver enzymes), but these changes represent physiological stress and tissue microtrauma rather than chronic disease or injury.Good
- Hyponatremia is a risk in ultra-endurance events, particularly when excessive water consumption occurs without adequate sodium replenishment, though it is uncommon in standard marathons.Good
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