Research

Mixed

Adhering to a low-carbohydrate diet (defined as the lowest quartile of carbohydrate intake, <42.7% of energy) is associated with a significantly higher risk of developing incident atrial fibrillation compared to higher carbohydrate intake, regardless of whether the replaced carbohydrates are substituted with animal or plant-based fats and proteins.

If you follow a low-carbohydrate diet, be aware that long-term adherence may be associated with a higher risk of developing atrial fibrillation (an irregular heart rhythm). This risk appears to exist regardless of whether you replace carbohydrates with animal or plant-based foods. If you have risk factors for heart disease or AF, consider discussing your carbohydrate intake with a healthcare provider to balance weight management goals with cardiac rhythm health.

GoodRefutesHIGH confidence
Low-carbohydrate diets were associated with increased risk of incident AF, regardless of the type of protein or fat used to replace the carbohydrate.
Shaozhao Zhang et al. · Journal of the American Heart Association · 2019

Why this rating

Large prospective cohort (ARIC), long follow-up (median 22.4 years), rigorous adjustment for confounders, but observational design prevents causal inference and relies on self-reported dietary data.

Source

Low‐Carbohydrate Diets and Risk of Incident Atrial Fibrillation: A Prospective Cohort Study

Shaozhao Zhang et al. · Journal of the American Heart Association · 2019

DOI 10.1161/jaha.119.011955

cohort · n=13385Cited 42×
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DOI resolved against Crossref · corpus check 2026-06-10

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