Hormonal
Pinitol-enriched beverage intake increases serum levels of Complement C4A and IGF1BP-ALS in individuals with Impaired Glucose Tolerance (IGT), which correlates with increased GLUT2 expression in the jejunum.
This node describes the biological mechanism rather than a direct user action. It suggests that the glucose-lowering effect of pinitol is mediated by specific protein changes (C4A, IGF1BP-ALS) and gut glucose transporter expression (GLUT2), particularly in those with pre-diabetic conditions.
Six weeks of pinitol-enriched beverage intake induced a significant increase in two proteins involved in the insulin secretion pathway, insulin-like growth factor acid labile subunit (IGF1BP-ALS; 1.3-fold increase; P = 0.200) and complement C4A (1.83-fold increase; P = 0.007) in IGT subjects but not in healthy volunteers.
Why this rating
The finding is supported by proteomic analysis in humans and Western blot/PCR in animal models, but the human sample size for the specific proteomic spots was small (N=6).
Source
Effects of a Carob-Pod-Derived Sweetener on Glucose Metabolism
Carmen Lambert et al. · Nutrients · 2018
DOI 10.3390/nu10030271
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