Macro partitioning
A short-term high-fat diet (65% energy from fat) for 5 days reduces large VLDL particles and small HDL particles (HDL-3/4) in men with overweight/obesity, which may be beneficial for cardiovascular health.
A short-term high-fat diet (65% of calories from fat) in sedent overweight men can improve specific lipid subfractions (reducing large VLDL and small HDL) which are linked to lower cardiovascular risk. However, this is a short-term effect in a controlled setting and should not be interpreted as a long-term dietary recommendation without medical supervision.
Consumption of an HFD for 5 days reduced the total fasting concentrations of cholesterol, free cholesterol, and phospholipids in VLDL... The HFD induced significant reductions in several HDL-related variables... reduced triglyceride enrichment in HDL-3 and HDL-4, indicating a beneficial effect of HFD since triglyceride concentrations in these small HDL particles are associated with risk of myocardial infarction.
Why this rating
Randomized controlled trial with rigorous dietary control, but short duration and small sample size.
Source
Effect of high-fat diet and morning or evening exercise on lipoprotein subfraction profiles: secondary analysis of a randomised trial
Trine Moholdt et al. · Scientific Reports · 2023
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