Research
Hormonal
Higher expression of Cardiotrophin-1 (CT-1) in subcutaneous femoral adipose tissue (scFEM) is associated with lower visceral adiposity, lower intrahepatic lipid, and greater insulin sensitivity in women with obesity.
For women with obesity, higher levels of the adipokine CT-1 in the femoral (thigh/buttock) fat depot are linked to better metabolic health, including lower liver fat and better insulin sensitivity. This suggests that lower-body fat distribution may be metabolically protective compared to abdominal fat, potentially mediated by CT-1 secretion.
ModerateSupportsMEDIUM confidence
scFEM but not scABD, CT-1 expression was negatively associated with visceral adiposity and intrahepatic lipid, while positively correlated with insulin sensitivity in obese women.
Why this rating
Observational correlation in a small sample size (N=22 women); no causation established.
Source
The Expression of Adipose Tissue-Derived Cardiotrophin-1 in Humans with Obesity
Jacqueline M. Stephens et al. · Biology · 2019
DOI 10.3390/biology8020024
cross_sectional · n=37Cited 8×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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