Research
Hormonal
Higher baseline expression of Cardiotrophin-1 (CT-1) in subcutaneous abdominal adipose tissue (scABD) protects men from the decline in insulin sensitivity typically caused by sustained overfeeding.
In lean men, higher baseline levels of the adipokine CT-1 in abdominal fat are associated with better preservation of insulin sensitivity during periods of overeating. This suggests that individual differences in adipose tissue biology may protect against diet-induced metabolic decline.
ModerateSupportsMEDIUM confidence
men with higher CT-1 levels at baseline had less of a decline in insulin sensitivity in response to overfeeding.
Why this rating
Observational correlation in a small sample size (N=15 men); no causation established.
Source
The Expression of Adipose Tissue-Derived Cardiotrophin-1 in Humans with Obesity
Jacqueline M. Stephens et al. · Biology · 2019
DOI 10.3390/biology8020024
cross_sectional · n=37Cited 8×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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