Mixed
In patients with Obstructive Sleep Apnea (OSA) treated with CPAP, a history of prior vascular events, hypertension, older age at treatment initiation, and higher comorbidity burden are significant independent risk factors for subsequent vascular events, whereas obesity (BMI) is not.
If you have OSA and use CPAP, adherence is crucial, but it does not guarantee immunity from heart issues. Your risk of a vascular event is significantly higher if you have high blood pressure, a history of heart problems, or other chronic conditions. Focus on managing your blood pressure and comorbidities alongside your CPAP therapy, and seek early diagnosis and treatment to mitigate age-related risks.
In the adjusted analysis, only age at initiation of OSA treatment with CPAP (HR: 1.025; 95%CI 1.012–1.037; p < 0.001), having suffered from a vascular event prior to initiation of treatment (HR: 2530; 95%CI 1.959–3.266; p < 0.001), suffering from high blood pressure (HR: 1.871; 95%CI 1.187–2.672; p = 0.005) and the abbreviated Charlson comorbidity index (HR: 1.289; 95%CI 1.100–1.510; p = 0.002) were related to vascular events.
Why this rating
Large sample size (n=2751), long follow-up (mean 2603 days), and robust statistical adjustment (Cox regression), though it is a retrospective observational study.
Source
Influence of Comorbidity and Obesity on the Occurrence of Vascular Events in Obstructive Apnoea Treated with CPAP
Inmaculada Jurado-Robles et al. · Nutrients · 2024
DOI 10.3390/nu16183071
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