Mixed
Greater weight loss (≥10%) is associated with a greater reduction in HVPG, and higher physical activity levels (METs) are associated with greater HVPG reduction, suggesting independent benefits of weight loss and exercise on portal pressure.
While the intervention is safe for all, patients aiming for maximum portal pressure reduction should target at least 10% body weight loss and engage in higher volumes of physical activity (measured in METs), as these factors are independently associated with greater improvements in hepatic hemodynamics.
A ≥10% body weight loss was associated with a greater decrease in HVPG (-23.7±19.9% vs. -8.2±16.6%, p=0.024)... A more intense physical activity, namely above the median of the study group (METs: 400.5 over 16 weeks)... was associated with a more marked decrease in HVPG
Why this rating
Observational analysis within a pilot study; correlation does not prove causation, but the trend is statistically significant.
Source
Effects of an intensive lifestyle intervention program on portal hypertension in patients with cirrhosis and obesity: The SportDiet study
Annalisa Berzigotti et al. · Hepatology · 2016
DOI 10.1002/hep.28992
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →