Research
Energy balance
Long-term negative energy balance via exercise shifts substrate oxidation toward lipids during submaximal exercise, a trait that is also genetically influenced.
Consistent moderate exercise over months teaches your body to burn more fat as fuel during activity. This is an adaptation to the energy deficit, not just the exercise intensity itself.
ModerateSupportsMEDIUM confidence
At the same submaximal power output level, subjects oxidized more lipids than carbohydrates after the program as indicated by the changes in the respiratory exchange ratio (p < 0.05).
Why this rating
Statistically significant but smaller effect size and sample size for this specific metric (n=5 pairs for RER data).
Source
The Response to Exercise with Constant Energy Intake in Identical Twins
Claude Bouchard et al. · Obesity Research · 1994
DOI 10.1002/j.1550-8528.1994.tb00087.x
rct · n=14Cited 320×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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