Research

Energy balance

Reduction in 30-year cardiovascular disease risk (CVDRisk30y) is significantly correlated with changes in body fat percentage (%BF) and skeletal muscle percentage (%MM) following TRF, even without changes in traditional blood biomarkers.

Focus on losing body fat and maintaining muscle mass through your TRF protocol, as these changes are the primary drivers for lowering your long-term cardiovascular risk score. Traditional blood tests may not reflect these improvements, so tracking body composition is a more useful metric for this specific intervention.

ModerateSupportsMEDIUM confidence
TRF promoted a reduction in CVDRisk30y (12%)... moderately correlated with %BF (r = 0.62, n = 64, p < 0.001) and %MM (r = -0.74, n = 64, p < 0.001).
Jéssica Daniela Schröder et al. · Journal of Translational Medicine · 2021

Why this rating

Based on the same non-randomized trial with small sample size.

Source

Effects of time-restricted feeding in weight loss, metabolic syndrome and cardiovascular risk in obese women

Jéssica Daniela Schröder et al. · Journal of Translational Medicine · 2021

DOI 10.1186/s12967-020-02687-0

clinical_trial · n=32Cited 144×
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DOI resolved against Crossref · corpus check 2026-06-10

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