Adherence
Continued structured support for weight loss maintenance in type 2 diabetes remission significantly reduces the incidence of moderate/major adverse cardiovascular events (MMACE) compared to standard care, with the benefit persisting over 5 years.
If you have achieved type 2 diabetes remission through weight loss, do not stop your efforts. The study shows that continuing structured support and maintaining your weight loss significantly lowers your risk of heart attacks and strokes over the next 5 years. Treat remission as a long-term commitment, not a one-time fix.
Table S7: Intervention vs Control MMACE Est (CI), p-value Year 2: 0.3 (0.1, 0.9), p=0.024NB; Year 5: 0.3 (0.1, 0.8), p=0.014NB. Table S8: Control vs Intervention MMACE Est (CI), p-value 1.1 (0.6, 2.1), p=0.80NB.
Why this rating
Randomized controlled trial extension study with long-term follow-up (5 years) and statistically significant results for MMACE in specific years.
Source
5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study
Michael EJ Lean et al. · The Lancet Diabetes & Endocrinology · 2024
DOI 10.1016/s2213-8587(23)00385-6
Related findings · Adherence
- Regular physical activity (at least 150 minutes/week of moderate-intensity) reduces all-cause and cardiovascular mortality by 20-30% and lowers the risk of type 2 diabetes by 25-35%.Strong
- Increasing physical activity from a sedentary lifestyle to an active one in middle adulthood significantly reduces the risk of coronary events compared to remaining sedentary.Strong
- Resistance exercise is the only intervention capable of consistently restoring muscle function and strength in sarcopenia, partially overcoming age-related anabolic resistance.Strong
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