Adherence
Continued structured support for weight loss maintenance in type 2 diabetes remission significantly reduces the incidence of moderate/major adverse cardiovascular events (MMACE) compared to standard care, with the benefit persisting over 5 years.
If you have achieved type 2 diabetes remission through weight loss, do not stop your efforts. The study shows that continuing structured support and maintaining your weight loss significantly lowers your risk of heart attacks and strokes over the next 5 years. Treat remission as a long-term commitment, not a one-time fix.
Table S7: Intervention vs Control MMACE Est (CI), p-value Year 2: 0.3 (0.1, 0.9), p=0.024NB; Year 5: 0.3 (0.1, 0.8), p=0.014NB. Table S8: Control vs Intervention MMACE Est (CI), p-value 1.1 (0.6, 2.1), p=0.80NB.
Why this rating
Randomized controlled trial extension study with long-term follow-up (5 years) and statistically significant results for MMACE in specific years.
Source
5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study
Michael EJ Lean et al. · The Lancet Diabetes & Endocrinology · 2024
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